Intended for US audiences only.

Tailored to Your Needs

Octapharma factor therapies replace the missing coagulation factor in patients with bleeding disorders to effectively control bleeding. Hemophilia A and von Willebrand disease patients alike take confidence in our disease-targeted medications, our production expertise with the highest standards for purity, and our years of commitment to improving the lives of those in the bleeding disorders community.

NUWIQ: A NATURAL CHOICE

NUWIQ is a recombinant Factor VIII (rFVIII) and is indicated for adults and children with hemophilia A for on-demand treatment and control of bleeding episodes, management of bleeding related to surgery, and routine prophylaxis to reduce the frequency of bleeding episodes.

NUWIQ is produced using human, rather than hamster, cells. In fact, no animal or human proteins are added during the manufacturing of NUWIQ.1,2

NUWIQ is:

  • Effective in controlling bleeding*,3
  • Not associated with the development of antibodies, also known as inhibitors, in studies with previously treated patients (PTPs) who switched to NUWIQ3
  • Safe in previously untreated patients (PUPs), with a low rate of inhibitor development†,4
  • Potentially able to extend dosing intervals in personalized prophylaxis5
  • Available in a wide range of dosage strengths for individual dosing needs
  • Simple and convenient to use3

Learn more about NUWIQ for hemophilia A

*The formation of neutralizing antibodies (inhibitors) to Factor VIII can occur following the administration of NUWIQ.

In the NuProtect study, 105 PUPs were treated with NUWIQ for prophylaxis or on-demand treatment and were followed for 100 exposure days or 5 years. 17 (16.2%) developed high-titer inhibitors and 11 (10.5%) developed low-titer inhibitors, 5 of whom had transient inhibitors.

NUWIQ is not indicated for the treatment of von Willebrand disease.

wilate: THE POWER OF BALANCE

wilate is a von Willebrand Factor (VWF) / Factor VIII (FVIII) complex developed specifically for the treatment of von Willebrand disease. It is indicated for children and adults with VWD for on-demand treatment and control of bleeding episodes and for management of bleeding related to surgery.

wilate is:

  • A balanced 1:1 formulation of VWF/FVIII, similar to the ratio found naturally in the body6,7,8
  • Effective at control of major and minor bleeding8
  • Prescribed at low recommended dosing*,6
  • Without accumulation of FVIII during repeat dosing in surgery9
  • A high-purity complex with double virus inactivation6
  • Simple and convenient to use6

*Based on the Recommended Dosing Guide for wilate. See Dosage and Administration, section 2.1 of full Prescribing Information.

Learn more about wilate for VWD

wilate is also indicated in adolescents and adults with hemophilia A for routine prophylaxis to reduce the frequency of bleeding episodes and for on-demand treatment and control of bleeding episodes

Learn more about wilate for hemophilia A

References

1. Sandberg H. et al., ‘Functional characteristics of the novel, human-derived recombinant FVIII protein product, human-cl rhFVIII’,Thrombosis Research, 2012, pp.808-817.

2. Casademunt E. et al., ‘The first recombinant human coagulation factor VIII of human origin: human cell line and manufacturing characteristics’, European Journal of Haematolgy, 2012, pp.165-176.

3. NUWIQ full Prescribing Information, Octapharma USA, 2017.

4. Liesner, R., and E. Neufeld, ‘Inhibitor Development with Simoctocog Alfa in Previously Untreated Patients with Severe Haemophilia a: Final Results of the Nuprotect Study’, Blood, 2019, https://doi.org/10.1182/blood-2019-125520, (accessed 14 October 2020)

5. Lissitchkov T. et al., ‘PK-guided personalized prophylaxis with Nuwiq® (human-cl rhFVIII) in adults with severe haemophilia A’, Haemophilia, 2017, pp. 697-704.

6. wilate Full Prescribing Information, Octapharma USA, 2016.

7. Stadler M. et al., ‘Characterisation of a novel high-purity, double virus inactivated von Willebrand Factor and Factor VIII concentrate (Wilate®)’, Biologicals, 2006.

8. Berntorp E. et al., ‘Treatment and prevention of acute bleedings in von Willebrand disease – efficacy and safety of Wilate®, a new generation von Willebrand factor/factor VIII concentrate’, Haemophilia, 2009, p. 123.

9. Srivastava A. et al., ‘Efficacy and safety of a VWF/FVIII concentrate (wilate®) in inherited von Willebrand disease patients undergoing surgical procedures’, Haemophilia. 2017, p. 268

COAG-0276
Indications and Important Safety Information for NUWIQ® and wilate®.
Indications and Important Safety Information for NUWIQ® [Antihemophilic Factor (Recombinant)]
Indicaciones e Información de seguridad importante de NUWIQ® [factor antihemofílico (recombinante)].
Consulte la Información de prescripción completa de NUWIQ. Instrucciones de uso
Indications and Important Safety Information for wilate® [von Willebrand Factor/Coagulation Factor VIII Complex (Human)].
Indicaciones e Información de seguridad importante de wilate® [complejo de factor de von Willebrand/factor VIII de la coagulación (humanos)].